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CAMP Seminar: Specificity, efficiency and processivity in the eukaryotic protein degradation system

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Ying Lu, Harvard University
When
28 November 2017 from 3:30 PM to 3:30 PM
Where
339 Davey Laboratory
Contact Name
Lu Bai
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Dynamic regulation of protein expression level is achieved by a combination of synthesis and degradation.  Protein degradation demonstrates remarkable specificity and processivity; it is essential for the proper function of a large number of biological processes such as cell division, differentiation, and cell homeostasis.  In the classic model of a biochemical reaction, specificity was often described with the image of key and lock. Kinetic mechanisms can also greatly enhance that specificity, but at the expense of reaction efficiency and energy dissipation. I will present my recent progress about how the Anaphase Promoting Complex achieves substrate specificity through Processive Affinity Amplification.  In the second part of the talk, I will discuss how the 26S proteasome – a universal degradation “machine” functions to be both specific and efficient against cellular proteins.  We expect these results to be helpful in elucidating the various specificity events in protein degradation and lead to general investigations of specificity in many cellular systems. 

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