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CAMP: How Proteins Deal with Entropy and Noise

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Milo Miaoyu Lin, University of California, Berkeley
10 February 2015 from 3:00 PM to 4:15 PM
339 Davey Laboratory
Contact Name
Dezhe Jin
Contact Phone
(814) 863-6673
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In the current era of Big Data, obtaining mechanistic insight into cellular biochemistry remains a challenge. The heterogeneity and complexity of biochemical systems has reinforced the paradigm that they are too detail-sensitive to be described by general rules governing their emergent behavior. In this talk, I will describe some research that contradicts the detail-sensitive paradigm for protein folding, self-assembly and function. This work, which comes from developing and applying new approaches from statistical mechanics and computational modeling, shows that diverse proteins, despite folding into unique structures to perform different functions, obey general quantitative rules. These rules govern maximum protein size, intra-protein communication efficiency, and critical transitions in protein self-assembly. Experimental validation, as well as how this work can trigger further avenues of exploration and drug design, will also be discussed.